CD34單克隆抗體 - 北京拜爾迪生物技術有限公司

CD34單克隆抗體

產品貨號：

BN42053M
中文名稱：

CD34單克隆抗體
英文名稱：

Mouse anti-CD34 Monoclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN42053M-50ul

50ul

￥1486.00

交叉反應：Human 推薦應用：WB,IHC-F,IF,ELISA
BN42053M-100ul

100ul

￥2360.00

交叉反應：Human 推薦應用：WB,IHC-F,IF,ELISA

產品描述

英文名稱	CD34
中文名稱	CD34單克隆抗體
別名	CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN; Hematopoietic Stem Cell Marker; Endothelial Markers; Tumor biomarkers.
研究領域	腫瘤心血管細胞生物干細胞細胞粘附分子細胞表面分子糖蛋白血管內皮細胞
抗體來源	Mouse
克隆類型	Monoclonal
克隆號	5B4
交叉反應	Human,
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	39kDa
細胞定位	細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human CD34 :32-290/385
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. Hematopoietic Stem Cell Marker Endothelial Markers Tumor biomarkers Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Post-translational modifications: Highly glycosylated. Phosphorylated on serine residues by PKC. Similarity: Belongs to the CD34 family. SWISS: P28906 Gene ID: 947 Database links: Entrez Gene: 947 Human Omim: 142230 Human SwissProt: P28906 Human Unigene: 374990 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.