異染色質蛋白1-γ/HP-1γ單克隆抗體

產品貨號：

BN42046M
中文名稱：

異染色質蛋白1-γ/HP-1γ單克隆抗體
英文名稱：

Mouse anti-HP1 gamma Monoclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN42046M-50ul

50ul

￥1486.00

交叉反應：Human,Mouse,Rat 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
BN42046M-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	HP1 gamma
中文名稱	異染色質蛋白1-γ/HP-1γ單克隆抗體
別名	CBX 3; CBX3; Chromobox homolog 3; Chromobox protein homolog 3; HECH; Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma; Heterochromatin protein HP1 gamma; HP1 gamma homolog; HP1Hs gamma ; Modifier 2; protein HP1-GAMMA; HP1g; M32; MGC118084; CBX3_HUMAN; Modifier 2 protein;
研究領域	腫瘤細胞生物染色質和核信號
抗體來源	Mouse
克隆類型	Monoclonal
克隆號	5B9
交叉反應	Human, Mouse, Rat,
產品應用	ELISA=1:1000-5000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	21kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human HP1 gamma Protein:
亞型	IgG
純化方法	affinity purified by Protein G
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Function: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Subunit: Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A. Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1. Subcellular Location: Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). Post-translational modifications: Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. Similarity: Contains 2 chromo domains. SWISS: Q13185 Gene ID: 11335 Database links: Entrez Gene: 11335 Human Entrez Gene: 12417 Mouse Entrez Gene: 297093 Rat Omim: 604477 Human SwissProt: Q13185 Human SwissProt: P23198 Mouse Unigene: 381189 Human Unigene: 280968 Mouse Unigene: 458234 Mouse Unigene: 485141 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.