絲裂原活化蛋白激酶組織蛋白1抗體

產品貨號：

BN41229R
中文名稱：

絲裂原活化蛋白激酶組織蛋白1抗體
英文名稱：

Rabbit anti-MAPK organizer 1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41229R-100ul

100ul

￥2360.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41229R-200ul

200ul

￥3490.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	MAPK organizer 1
中文名稱	絲裂原活化蛋白激酶組織蛋白1抗體
別名	MAPK organizer 1; MGC4238; Mitogen activated protein kinase organizer 1; Mitogen-activated protein kinase organizer 1; MORG 1; WD repeat domain-containing protein 83; wdr83; WDR83_HUMAN.
研究領域	心血管細胞生物信號轉導激酶和磷酸酶
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	35kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human MAPK organizer 1:201-315/315
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Function: Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. Subunit: Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1. Identified in the spliceosome C complex. Subcellular Location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. Similarity: Belongs to the WD repeat MORG1 family. Contains 7 WD repeats. SWISS: Q9BRX9 Gene ID: 84292 Database links: Entrez Gene: 84292 Human Entrez Gene: 67836 Mouse Entrez Gene: 288924 Rat SwissProt: Q9BRX9 Human SwissProt: Q9DAJ4 Mouse SwissProt: Q5BLX8 Rat Unigene: 657204 Human Unigene: 334680 Mouse Unigene: 3570 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.