NADH脫氫酶黃素蛋白1抗體

產品貨號：

BN40985R
中文名稱：

NADH脫氫酶黃素蛋白1抗體
英文名稱：

Rabbit anti-NDUFV1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40985R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN40985R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	NDUFV1
中文名稱	NADH脫氫酶黃素蛋白1抗體
別名	CI 51kD; Complex I 51kD; NADH dehydrogenase (ubiquinone) flavoprotein 1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NADH dehydrogenase flavoprotein 1; NADH ubiquinone oxidoreductase 51 kDa subunit; NADH ubiquinone oxidoreductase; NDUFV 1; UQOR1; NDUV1_HUMAN.
研究領域	腫瘤細胞生物免疫學線粒體
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	49kDa
細胞定位	細胞漿細胞膜線粒體
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human NDUFV1:41-140/464
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009] Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Subunit: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Subcellular Location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. DISEASE: Defects in NDUFV1 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Similarity: Belongs to the complex I 51 kDa subunit family. SWISS: P49821 Gene ID: 4723 Database links: Entrez Gene: 287014 Cow Entrez Gene: 4723 Human Entrez Gene: 17995 Mouse Entrez Gene: 293655 Rat Omim: 161015 Human SwissProt: P25708 Cow SwissProt: P49821 Human SwissProt: Q91YT0 Mouse SwissProt: Q5XIH3 Rat Unigene: 7744 Human Unigene: 29842 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application