細胞色素P450 2R1抗體

產品貨號：

BN40977R
中文名稱：

細胞色素P450 2R1抗體
英文名稱：

Rabbit anti-CYP2R1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40977R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN40977R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱	CYP2R1
中文名稱	細胞色素P450 2R1抗體
別名	Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase.
研究領域	腫瘤心血管細胞生物免疫學信號轉導
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, (predicted: Rat, Dog, Pig, Horse, Rabbit, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	55kDa
細胞定位	細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human CYP2R1:251-350/501
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency, also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D. Subunit: Homodimer. Subcellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Tissue Specificity: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Similarity: Belongs to the cytochrome P450 family. SWISS: Q6VVX0 Gene ID: 120227 Database links: Entrez Gene: 120227 Human Entrez Gene: 244209 Mouse Omim: 608713 Human SwissProt: Q6VVX0 Human SwissProt: Q6VVW9 Mouse Unigene: 371427 Human Unigene: 108037 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.