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      首頁>>免疫學>>一抗>>磷酸化p53結合蛋白1抗體  
      

      

      
	
      
    	
      
        	
      磷酸化p53結合蛋白1抗體
       
      
            
      
            	
      
            	
      
                	
        
                    	
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        產品貨號：
        
                            
        BN40845R
        
                        
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        中文名稱：
        
                            
        磷酸化p53結合蛋白1抗體 
        
                        
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        英文名稱：
        
                            
        Rabbit anti-phospho-p53BP1 (Ser25 + Ser29) Polyclonal antibody 
        
                        
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        品牌：
        
                            
        Biorigin 
        
                        
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        貨號
        
                                
        產品規格
        
                                
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        BN40845R-100ul
        
                                
        100ul
        
                                
        ￥2470.00
        
                                
        交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit)   推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
        
                            
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      產品描述
      
                
      
                
      
                	
      英文名稱phospho-p53BP1 (Ser25 + Ser29)
      中文名稱磷酸化p53結合蛋白1抗體
      別    名53BP1 (phospho S25); p-53BP1 (phospho S25) ;53BP1 (Phospho-Ser25/29); 53BP1 (Phospho-S25/S29); phospho-p53BP1(Ser25/Ser29); P-53BP1 (Ser25/29); 53 BP1; FLJ41424; MGC138366; p202; p53 binding protein 1; p53 BP1; p53BP1; TP53 BP1; TP53BP1; Tumor protein 53 binding protein 1; Tumor protein p53 binding protein 1; Tumor suppressor p53 binding protein 1; TP53B_HUMAN; tumor protein 53-binding protein, 1.  



      產品類型磷酸化抗體 
      研究領域腫瘤  細胞生物  染色質和核信號  信號轉導  激酶和磷酸酶  結合蛋白  表觀遺傳學  
      抗體來源Rabbit
      克隆類型Polyclonal
      交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, )
      產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      分 子 量213kDa
      細胞定位細胞核 
      性    狀Liquid
      濃    度1mg/ml
      免 疫 原KLH conjugated Synthesised phosphopeptide derived from human p53BP1 around the phosphorylation site of Ser25/29:ED(p-S)QPE(p-S)QV 
      亞    型IgG
      純化方法affinity purified by Protein A
      儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
      保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
      PubMedPubMed
      產品介紹p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.

      Function:
      May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.

      Subunit:
      Interacts with IFI202A. Binds to the central domain of p53/TP53. May form homooligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20' (H4K20me2). Has low affinity for histone H4 containing monomethylated 'Lys-20' (H4K20me1). Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20' (H4K20me3). Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3. Interacts with MUM1/EXPAND1. Interacts with CHEK2; modulates CHEK2 phosphorylation at 'Thr-68' in response to infrared. Interacts with MSL1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity.

      Subcellular Location:
      Nucleus. Chromosome; centromere; kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.

      Post-translational modifications:
      Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.
      Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.

      DISEASE:
      Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.

      Similarity:
      Contains 2 BRCT domains.

      SWISS:
      Q12888

      Gene ID:
      7158

      Database links:
      Entrez Gene: 7158 Human
      Entrez Gene: 27223 Mouse
      Omim: 605230 Human
      SwissProt: Q12888 Human
      SwissProt: P70399 Mouse
      Unigene: 440968 Human
      Unigene: 383499 Mouse
      Unigene: 481841 Mouse


      Important Note:
      This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

      p53結合蛋白1(53BP1)是細胞周期檢查點激酶蛋白，是新近發現的DNA損傷修復通路中兩個非常重要的蛋白激酶MDC1和53BP1蛋白之一,目前多用于腫瘤方面的研究。





















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