組蛋白去乙?；?0抗體

產品貨號：

BN40837R
中文名稱：

組蛋白去乙?；?0抗體
英文名稱：

Rabbit anti-HDAC10 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40837R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA
BN40837R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	HDAC10
中文名稱	組蛋白去乙?；?0抗體
別名	HD 10; HD10; HDAC 10; Histone deacetylase 10; MGC149722; OTTHUMP00000028555; DKFZP761B039; HDA10_HUMAN; Histone deacetylase 10; HD10.
研究領域	腫瘤免疫學發育生物學信號轉導細胞凋亡轉錄調節因子
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Pig, Cow, Horse, Rabbit, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	71kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human HDAC10:561-669/669
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The enzymes responsible for the reversible acetylation/ deacetylation process of histones are histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. HATs act as transcriptional coactivators and HDACs are part of transcriptional corepressor complexes. Mammalian HDACs can be divided into three classes according to sequence homology. Class I consists of the yeast Rpd3 like proteins HDAC1, HDAC2, HDAC3, and HDAC8. Class II consists of the yeast Hda1 like proteins HDAC10, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10. Class III comprises the yeast Sir2 like proteins. Whereas class I HDACs are ubiquitously expressed, most class II HDACs are tissue specific. HDAC10 is similar to HDAC6, both containing a unique putative second catalytic domain not found in other HDACs. However, this domain is not functional in HDAC10. The deacetylase activity of class II HDACs is regulated by subcellular localization. HDAC10 was localized to both the nucleus and cytoplasm. HDAC10 can deacetylate histones, repress transcription, and interact with HDAC3. Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Subunit: Interacts with HDAC2, HDAC3 and NCOR2. Subcellular Location: Cytoplasm. Nucleus. Note=Excluded from the nucleoli. Tissue Specificity: Ubiquitous. High expression in liver, spleen, pancreas and kidney. Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily. SWISS: Q969S8 Gene ID: 83933 Database links: Entrez Gene: 83933 Human Entrez Gene: 170787 Mouse Entrez Gene: 362981 Rat Omim: 608544 Human SwissProt: Q969S8 Human SwissProt: Q6P3E7 Mouse SwissProt: Q569C4 Rat Unigene: 26593 Human Unigene: 203954 Mouse Unigene: 107028 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.