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      首頁>>免疫學>>一抗>>組蛋白去乙?；?抗體  
      

      

      
	
      
    	
      
        	
      組蛋白去乙?；?抗體
       
      
            
      
            	
      
            	
      
                	
        
                    	
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        產品貨號：
        
                            
        BN40834R
        
                        
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        中文名稱：
        
                            
        組蛋白去乙?；?抗體 
        
                        
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        英文名稱：
        
                            
        Rabbit anti-HDAC6 Polyclonal antibody 
        
                        
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        品牌：
        
                            
        Biorigin 
        
                        
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        貨號
        
                                
        產品規格
        
                                
        售價
        
                                
        備注
        
                            
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        BN40834R-100ul
        
                                
        100ul
        
                                
        ￥2360.00
        
                                
        交叉反應：Human,Rat(predicted:Mouse,Cow,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
        
                            
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        BN40834R-200ul
        
                                
        200ul
        
                                
        ￥3490.00
        
                                
        交叉反應：Human,Rat(predicted:Mouse,Cow,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
        
                            
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      產品描述
      
                
      
                
      
                	
      英文名稱HDAC6
      中文名稱組蛋白去乙?；?抗體
      別    名HD 6; HD6; HDAC 6; Histone deacetylase 6; HD6; Histone deacetylase 6; JM 21; JM21; KIAA0901; FLJ16239; HDAC6_HUMAN.  
      研究領域腫瘤  發育生物學  信號轉導  細胞凋亡  轉錄調節因子  表觀遺傳學  
      抗體來源Rabbit
      克隆類型Polyclonal
      交叉反應Human, Rat,  (predicted: Mouse, Cow, Horse, Rabbit, )
      產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      分 子 量134kDa
      細胞定位細胞核 細胞漿 
      性    狀Liquid
      濃    度1mg/ml
      免 疫 原KLH conjugated synthetic peptide derived from human HDAC6:301-400/1215 
      亞    型IgG
      純化方法affinity purified by Protein A
      儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
      保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
      PubMedPubMed
      產品介紹Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008].

      Function:
      Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
      In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

      Subunit:
      Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP.

      Subcellular Location:
      Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.

      Post-translational modifications:
      Phosphorylated by AURKA.
      Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
      Sumoylated in vitro.

      Similarity:
      Belongs to the histone deacetylase family. HD type 2 subfamily.
      Contains 1 UBP-type zinc finger.

      SWISS:
      Q9UBN7

      Gene ID:
      10013

      Database links:
      Entrez Gene: 10013 Human
      Entrez Gene: 15185 Mouse
      Entrez Gene: 84581 Rat
      Omim: 300272 Human
      SwissProt: Q9UBN7 Human
      SwissProt: Q9Z2V5 Mouse
      Unigene: 6764 Human
      Unigene: 29854 Mouse
      Unigene: 13453 Rat


      Important Note:
      This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

       組蛋白去乙?；?HDACs)是一組在細胞染色質水平、通過誘導組蛋白去乙?；瘉碚{控包括染色質重組、轉錄活化或抑制、細胞周期、細胞分化及細胞凋亡等一系列生物學效應的酶，特別是與細胞活化后的基因轉錄表達調控有關。
          HDAC6是一種比較獨特的組蛋白去乙?；?，含有兩個功能上相互獨立的HDAC催化結構域。HDAC6可以去乙?；M蛋白并抑制相關基因轉錄。
          HDAC6可以和微管(microtuble)結合，可以去乙?；痶ubulin，Hsp90和cortactin等。目前發現大量的蛋白可以被乙?；揎?，因此HDAC等乙?；揎椕副徽J為在基因轉錄調控、信號轉導、生長發育、分化凋亡、代謝性疾病和腫瘤等多種生理病理過程中發揮重要作用。HDAC的抑制劑目前被認為是很有前景的腫瘤治療藥物。
          內源性HDAC6主要定位于細胞漿，與微管相結合并且是一個微管蛋白去乙?；?。HDAC6含有一個鋅指結構域，該結構域可能和泛素化降解的調節有關。HDAC6可以和DHAC11相互作用。

                      
      
                
      
                	
        
                                                                    
      
                
      
                
            
      
        
      
    
      

      


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