胚胎干細胞關鍵蛋白抗體

產品貨號：

BN40762R
中文名稱：

胚胎干細胞關鍵蛋白抗體
英文名稱：

Rabbit anti-SOX2 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40762R-100ul

100ul

￥2360.00

交叉反應：Rat,Mouse(predicted:Sheep,Horse,Cow,Dog,Chicken,Human) 推薦應用：WB,IHC-P,IHC-F,ICC,IF
BN40762R-200ul

200ul

￥3490.00

交叉反應：Rat,Mouse(predicted:Sheep,Horse,Cow,Dog,Chicken,Human) 推薦應用：WB,IHC-P,IHC-F,ICC,IF

產品描述

英文名稱	SOX2
中文名稱	胚胎干細胞關鍵蛋白抗體
別名	transcriptional factor SOX2; ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MGC148683; MGC2413; RGD1565646; Sex determining region Y box 2; Sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY box containing gene 2; SRY related HMG box 2; SRY related HMG box gene 2; SRY-box 2; ysb; SOX2_HUMAN; Transcription factor SOX-2; SOX2_HUMAN.
研究領域	腫瘤細胞生物神經生物學干細胞
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Chicken, Dog, Cow, Horse, Sheep, )
產品應用	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	34kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human SOX2:1-100/317
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]. Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Subunit: Interacts with ZSCAN10. Interacts with SOX3 and FGFR1. Subcellular Location: Nucleus. Post-translational modifications: Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. DISEASE: Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. Similarity: Contains 1 HMG box DNA-binding domain. SWISS: P48431 Gene ID: 6657 Database links: Entrez Gene: 6657 Human Entrez Gene: 20674 Mouse Omim: 184429 Human SwissProt: P48431 Human SwissProt: P48432 Mouse Unigene: 518438 Human Unigene: 65396 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Embryonic Stem Cell Marker (胚胎干細胞標志物) 轉錄因子:胚胎干細胞相關蛋白Sox2是sox基因家族的一個成員,Sox2與Oct4、Nanog一樣是胚胎干細胞重要的轉錄因子，是維持干細胞特性中起到重要的作用因子；由于它在早期胚胎發生、神經分化和晶狀體發育等多種重要的發育事件中都起著關鍵的作用,從而引起了越來越廣泛的關注。