胰島素樣生長因子ⅡmRNA結合蛋白2抗體

產品貨號：

BN40713R
中文名稱：

胰島素樣生長因子ⅡmRNA結合蛋白2抗體
英文名稱：

Rabbit anti-IGF2BP2 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40713R-100ul

100ul

￥2360.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用：WB
BN40713R-200ul

200ul

￥3490.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用：WB

產品描述

英文名稱	IGF2BP2
中文名稱	胰島素樣生長因子ⅡmRNA結合蛋白2抗體
別名	Hepatocellular carcinoma autoantigen p62; IF2B2_HUMAN; IGF 2 mRNA binding protein 2; IGF II mRNA binding protein 2; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; Igf2bp2; IMP 2; IMP-2; IMP2; Insulin like growth factor 2 mRNA binding protein 2; Insulin-like growth factor 2 mRNA-binding protein 2; p62; VICKZ family member 2; VICKZ2; IGF2-BP2.
研究領域	腫瘤細胞生物免疫學信號轉導表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Rabbit, Sheep, )
產品應用	WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	66kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human IGF2BP2:191-290/599
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	IGF2BP2 (insulin-like growth factor 2 mRNA binding protein 2) is also known as IGF2 mRNA-binding protein 2, IMP-2 (IGF-II mRNA-binding protein 2), VICKZ family member 2 or hepatocellular carcinoma autoantigen p62 and is a 556 amino acid protein. IGF2BP2 is expressed in a variety of tissues including heart, placenta, skeletal muscle, pancreas, fetal liver, lung, kidney, thymus and gonadal cells. IGF2BP2 is an RNA binding protein which may be involved in the regulation of mRNA translation and may also function to control the spatial localization of target mRNAs. Antibodies against IGF2BP2 have been detected in patients with HCC (hepatocellular carcinoma), suggesting that IGF2BP2 may have a role in the pathogenesis of HCC. Defects in IGF2BP2 are thought to be associated with susceptibility to type 2 diabetes mellitus. Function: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs. Subunit: Interacts with HNRPD and IGF2BP1. Subcellular Location: Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. Tissue Specificity: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis. Similarity: Belongs to the RRM IMP/VICKZ family br>Contains 4 KH domains. Contains 2 RRM (RNA recognition motif) domains. SWISS: Q9Y6M1 Gene ID: 10644 Database links: Entrez Gene: 10644 Human Entrez Gene: 319765 Mouse Entrez Gene: 303824 Rat Omim: 608289 Human SwissProt: Q9Y6M1 Human SwissProt: Q5SF07 Mouse Unigene: 35354 Human Unigene: 489442 Mouse Unigene: 17318 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications