雙鏈RNA腺苷酸脫氨基酶抗體（C端）

產品貨號：

BN40669R
中文名稱：

雙鏈RNA腺苷酸脫氨基酶抗體（C端）
英文名稱：

Rabbit anti-ADAR1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40669R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN40669R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	ADAR1
中文名稱	雙鏈RNA腺苷酸脫氨基酶抗體（C端）
別名	136kDa double stranded RNA binding protein; Adar 1; ADAR; Adar1; Adenosine deaminase RNA specific 1; Adenosine deaminase RNA specific; Adenosine deaminase that act on RNA; AV242451; Double stranded RNA specific adenosine deaminase; Double-stranded RNA-specific editase Adar; Drada; Dsh; Dsrad; dsRNA adenosine deaminase; EC 3.5.4.-; G1P1; IFI 4; IFI4; Ifi4 protein; Interferon induced protein 4; Interferon inducible protein 4; K88dsrbp; mZaADAR; p136; Pre-mRNA adenosine deaminase; RNA adenosine deaminase 1; RNA-editing deaminase 1; RNA-editing enzyme 1.
研究領域	細胞生物免疫學細胞周期蛋白
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat,
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	135kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human DRADA:1001-1226/1226
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] Function: Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. Subunit: Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. Subcellular Location: Cytoplasm. Nucleus, nucleolus. Isoform 1: Cytoplasm. Note=Found predominantly in cytoplasm but appears to shuttle between the cytoplasm and nucleus. Isoform 5: Nucleus, nucleolus. Tissue Specificity: Ubiquitously expressed, highest levels were found in brain and lung. Post-translational modifications: Sumoylation reduces RNA-editing activity. DISEASE: Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria (DSH) [MIM:127400]; also known as reticulate acropigmentation of Dohi. DSH is a pigmentary genodermatosis of autosomal dominant inheritance characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the dorsal parts of the hands and feet. Similarity: Contains 1 A to I editase domain. Contains 2 DRADA repeats. Contains 3 DRBM (double-stranded RNA-binding) domains. SWISS: P55265 Gene ID: 103 Database links: Entrez Gene: 103 Human Entrez Gene: 56417 Mouse Omim: 146920 Human SwissProt: P55265 Human SwissProt: Q99MU3 Mouse Unigene: 12341 Human Unigene: 679967 Human Unigene: 316628 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.