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      首頁>>免疫學>>一抗>>骨保護蛋白配體/破骨細胞分化因子抗體  
      

      

      
	
      
    	
      
        	
      骨保護蛋白配體/破骨細胞分化因子抗體
       
      
            
      
            	
      
            	
      
                	
        
                    	
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        產品貨號：
        
                            
        BN40620R
        
                        
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        中文名稱：
        
                            
        骨保護蛋白配體/破骨細胞分化因子抗體 
        
                        
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        英文名稱：
        
                            
        Rabbit anti-RANKL/CD254 Polyclonal antibody 
        
                        
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        品牌：
        
                            
        Biorigin 
        
                        
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        貨號
        
                                
        產品規格
        
                                
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        BN40620R-100ul
        
                                
        100ul
        
                                
        ￥2360.00
        
                                
        交叉反應：Rat,Mouse,Human(predicted:Zebrafish,Rabbit,Horse,Cow,Pig,Dog)   推薦應用：WB,Flow-Cyt
        
                            
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        BN40620R-200ul
        
                                
        200ul
        
                                
        ￥3490.00
        
                                
        交叉反應：Rat,Mouse,Human(predicted:Zebrafish,Rabbit,Horse,Cow,Pig,Dog)   推薦應用：WB,Flow-Cyt
        
                            
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      產品描述
      
                
      
                
      
                	
      英文名稱RANKL/CD254
      中文名稱骨保護蛋白配體/破骨細胞分化因子抗體
      別    名OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.  


      研究領域腫瘤  細胞生物  免疫學  發育生物學  
      抗體來源Rabbit
      克隆類型Polyclonal
      交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
      產品應用WB=1:500-2000 Flow-Cyt=1ug/Test 
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      分 子 量35kDa
      細胞定位細胞漿 細胞膜 分泌型蛋白 
      性    狀Liquid
      濃    度1mg/ml
      免 疫 原KLH conjugated synthetic peptide derived from human RANKL/CD254:41-140/317 
      亞    型IgG
      純化方法affinity purified by Protein A
      儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
      保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
      PubMedPubMed
      產品介紹This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].

      Function:
      Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

      Subcellular Location:
      Cytoplasm; Secreted and Cell membrane.

      Tissue Specificity:
      Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

      Post-translational modifications:
      The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17.

      DISEASE:
      Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.

      Similarity:
      Belongs to the tumor necrosis factor family.

      SWISS:
      O14788

      Gene ID:
      8600

      Database links:
      Entrez Gene: 8600 Human
      Entrez Gene: 21943 Mouse
      Omim: 602642 Human
      SwissProt: O14788 Human
      SwissProt: O35235 Mouse
      Unigene: 333791 Human
      Unigene: 249221 Mouse


      Important Note:
      This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

      OPGL骨保護蛋白配體又稱骨保護素配體(破骨細胞發育刺激因子)。屬腫瘤壞死因子TNF-a家族。
      OPGL促進破骨細胞的分化和活性,而OPG抑制這些過程。骨髓瘤細胞影響骨髓中這兩種蛋白的生理平衡，是發生溶骨性病變的根本所在。























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