酪氨酸蛋白磷酸酶非受體型12抗體

產品貨號：

BN40568R
中文名稱：

酪氨酸蛋白磷酸酶非受體型12抗體
英文名稱：

Rabbit anti-PTPN12 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40568R-100ul

100ul

￥2360.00

交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,ELISA
BN40568R-200ul

200ul

￥3490.00

交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,ELISA

產品描述

英文名稱	PTPN12
中文名稱	酪氨酸蛋白磷酸酶非受體型12抗體
別名	Protein tyrosine phosphatase G1; Protein tyrosine phosphatase non receptor type 12; Protein-tyrosine phosphatase G1; PTN12_HUMAN; PTP PEST; PTP-PEST; PTPG1; Ptpn12; Tyrosine protein phosphatase non receptor type 12; Tyrosine-protein phosphatase non-receptor type 12.
研究領域	腫瘤細胞生物信號轉導細胞周期蛋白激酶和磷酸酶細胞分化
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	88kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human PTPN12:1-100/780
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] Function: Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2. Subunit: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN (By similarity). {ECO:0000250}. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000269\|PubMed:17046825}. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain. SWISS: Q05209 Gene ID: 5782 Database links: Entrez Gene: 5782 Human Entrez Gene: 531877 Cow Entrez Gene: 19248 Mouse Entrez Gene: 117255 Rat Omim: 600079 Human SwissProt: Q05209 Human SwissProt: P35831 Mouse SwissProt: Q63745 Rat Unigene: 34723 Cow Unigene: 61812 Human Unigene: 319117 Mouse Unigene: 10707 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.