異質核核糖核蛋白D樣蛋白抗體

產品貨號：

BN40493R
中文名稱：

異質核核糖核蛋白D樣蛋白抗體
英文名稱：

Rabbit anti-hnRNP DL Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40493R-100ul

100ul

￥2360.00

交叉反應：Mouse(predicted:Human,Rat,Chicken,Dog,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40493R-200ul

200ul

￥3490.00

交叉反應：Mouse(predicted:Human,Rat,Chicken,Dog,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	hnRNP DL
中文名稱	異質核核糖核蛋白D樣蛋白抗體
別名	A+U-rich element RNA binding factor; AA407431; AA959857; AU rich element RNA binding factor; AU-rich element RNA-binding factor; D5Ertd650e; D5Wsu145e; Heterogeneous nuclear ribonucleoprotein D like; Heterogeneous nuclear ribonucleoprotein D like protein; Heterogeneous nuclear ribonucleoprotein D-like; hnHNRP DL; HNRDL_HUMAN; HNRNP; hnRNP D-like; hnRNP DL; HNRNPDL; hnRPD like protein; JKT41 binding protein; JKT41-binding protein; JKTBP; JKTBP2; laAUF1; MGC125262; Protein laAUF1。
研究領域	細胞生物結合蛋白表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, (predicted: Human, Rat, Chicken, Dog, Cow, Sheep, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	46kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human hnRNP DL:101-200/420
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011] Function: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. Subcellular Location: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner. Tissue Specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells. Post-translational modifications: Dimethylation of Arg-408 is probably of the asymmetric type. Similarity: Contains 2 RRM (RNA recognition motif) domains. SWISS: O14979 Gene ID: 9987 Database links: Entrez Gene: 422601 Chicken Entrez Gene: 534770 Cow Entrez Gene: 9987 Human Entrez Gene: 50926 Mouse Entrez Gene: 305178 Rat Omim: 607137 Human SwissProt: Q5ZI72 Chicken SwissProt: O14979 Human SwissProt: Q9Z130 Mouse SwissProt: Q3SWU3 Rat Unigene: 527105 Human Unigene: 707013 Human Unigene: 389579 Mouse Unigene: 102146 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.