2'-5'-寡腺苷酸合成酶2抗體

產品貨號：

BN40467R
中文名稱：

2'-5'-寡腺苷酸合成酶2抗體
英文名稱：

Rabbit anti-OAS2 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40467R-100ul

100ul

￥2360.00

交叉反應：Mouse(predicted:Human,Dog,Pig) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
BN40467R-200ul

200ul

￥3490.00

交叉反應：Mouse(predicted:Human,Dog,Pig) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	OAS2
中文名稱	2'-5'-寡腺苷酸合成酶2抗體
別名	(2-5'')oligo(A) synthase 2; (2-5')oligo(A) synthetase 2; 2''-5''-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2; 2-5A synthetase 2; MGC78578; OAS2; OAS2_HUMAN; p69 OAS / p71 OAS; p69OAS / p71OAS.
研究領域	細胞生物免疫學染色質和核信號線粒體
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, (predicted: Human, Dog, Pig, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	82kDa
細胞定位	細胞核細胞漿線粒體
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human OAS2:401-500/719
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Function: Interferon-induced, dsRNA-activated antiviral enzymewhich plays a critical role in cellular innate antiviral response.In addition, it may also play a role in other cellular processessuch as apoptosis, cell growth, differentiation and generegulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form ofribonuclease L (RNase L) leading to its dimerization and subsequentactivation. Activation of RNase L leads to degradation of cellularas well as viral RNA, resulting in the inhibition of proteinsynthesis, thus terminating viral replication. Can mediate theantiviral effect via the classical RNase L-dependent pathway or analternative antiviral pathway independent of RNase L.[CATALYTIC ACTIVITY] 3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate. Subunit: Homodimer. Subcellular Location: Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum.Note=Associated with different subcellular fractions such asmitochondrial, nuclear, and rough/smooth microsomal fractions. Post-translational modifications: Myristoylation is not essential for its activity. Glycosylated. Glycosylation is essential for its activity. Similarity: Belongs to the 2-5A synthase family. SWISS: P29728 Gene ID: 4939 Database links: Entrez Gene: 4939 Human Entrez Gene: 246728 Mouse Omim: 603350 Human SwissProt: P29728 Human SwissProt: E9Q9A9 Mouse Unigene: 414332 Human Unigene: 260926 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.