兒茶酚O甲基移位酶抗體

產品貨號：

BN40461R
中文名稱：

兒茶酚O甲基移位酶抗體
英文名稱：

Rabbit anti-COMT Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40461R-100ul

100ul

￥2360.00

交叉反應：Mouse,Rat(predicted:Human,Pig,Cow,Horse) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
BN40461R-200ul

200ul

￥3490.00

交叉反應：Mouse,Rat(predicted:Human,Pig,Cow,Horse) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	COMT
中文名稱	兒茶酚O甲基移位酶抗體
別名	Catechol O methyltransferase; Catechol O-methyltransferase; COMT; COMT_HUMAN; EC 2.1.1.6.
研究領域	神經生物學信號轉導新陳代謝
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Pig, Cow, Horse, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	30kDa
細胞定位	細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human COMT:121-220/271
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Subcellular Location: Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side. Tissue Specificity: Brain, liver, placenta, lymphocytes and erythrocytes. Post-translational modifications: The N-terminus is blocked. Similarity: Belongs to the mammalian catechol-O-methyltransferase family. SWISS: P21964 Gene ID: 1312 Database links: Entrez Gene: 1312 Human Entrez Gene: 12846 Mouse Entrez Gene: 24267 Rat Omim: 116790 Human SwissProt: P21964 Human SwissProt: O88587 Mouse SwissProt: P22734 Rat Unigene: 370408 Human Unigene: 704514 Human Unigene: 100940 Mouse Unigene: 220 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.