磷酸化神經細胞鳥苷酸置換因子Ephexin1抗體

產品貨號：

BN40406R
中文名稱：

磷酸化神經細胞鳥苷酸置換因子Ephexin1抗體
英文名稱：

Rabbit anti-phospho-Ephexin-1 (Tyr179) Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40406R-100ul

100ul

￥2470.00

交叉反應：Human,Mouse,Rat(predicted:Chicken) 推薦應用：WB,ELISA

產品描述

英文名稱	phospho-Ephexin-1 (Tyr179)
中文名稱	磷酸化神經細胞鳥苷酸置換因子Ephexin1抗體
別名	Ephexin-1 (phospho Y179); p-Ephexin-1 (phospho Y179); ARHGEF27; Eph-interacting exchange protein; EPHEXIN; Ephexin 1; Neuronal guanine nucleotide exchange factor; Ngef; NGEF_HUMAN.
產品類型	磷酸化抗體
研究領域	細胞生物神經生物學信號轉導 G蛋白偶聯受體 G蛋白信號
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Chicken, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	82kDa
細胞定位	細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthesised phosphopeptide derived from human Ephexin-1 around the phosphorylation site of Tyr179:LL(p-Y)QE
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	EPHEXIN is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species. Function: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension. Subunit: Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase. Subcellular Location: Cytoplasm. Membrane. Cell projection, growth cone. Associated with membranes. Localizes to axonal growth cones. Tissue Specificity: Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. Post-translational modifications: Src-dependent phosphorylation at Tyr-179 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 SH3 domain. Database links : UniProtKB/Swiss-Prot: Q8N5V2.2 SWISS: Q8N5V2 Gene ID: 25791 Database links: Entrez Gene: 25791 Human Entrez Gene: 53972 Mouse Entrez Gene: 246217 Rat Entrez Gene: 424744 Chicken Omim: 605991 Human SwissProt: Q8N5V2 Human SwissProt: Q8CHT1 Mouse SwissProt: Q5BKC9 Rat Unigene: 97316 Human Unigene: 435439 Mouse Unigene: 20670 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.