神經特異性轉錄因子DPF1抗體

產品貨號：

BN40314R
中文名稱：

神經特異性轉錄因子DPF1抗體
英文名稱：

Rabbit anti-Neuro D Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40314R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40314R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	Neuro D
中文名稱	神經特異性轉錄因子DPF1抗體
別名	NeuroD4; BAF45B; BRG1-associated factor 45B; D4; DPF1; DPF 1; DPF=1; DPF1_HUMAN; NEUD4; NEUD 4; Zinc and double PHD fingers family 1; Zinc finger protein neuro-d4.
研究領域	細胞生物神經生物學信號轉導轉錄調節因子表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Sheep, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	42kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Neuro D4:301-380/380
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	DPF1 is a 353 amino acid protein that contains two PHD-type zinc fingers and belongs to the requiem/DPF family. Localized to both the nucleus and the cytoplasm, DPF1 is thought to play an important role in the regulation of neuronal cell survival. Specifically, DPF1 may function as a neurospecific transcription factor that binds DNA and participates in cell cycle progression. Human and rat DPF1 share 93% sequence identity, suggesting a conserved role between species. Multiple isoforms of DPF1 exist due to alternative splicing events. Function: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Subunit: Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the requiem/DPF family. Contains 2 PHD-type zinc fingers. SWISS: Q92782 Gene ID: 8193 Database links: Entrez Gene: 8193 Human Entrez Gene: 29861 Mouse Entrez Gene: 50545 Rat SwissProt: Q92782 Human SwissProt: Q9QX66 Mouse SwissProt: P56163 Rat Unigene: 631576 Human Unigene: 101885 Mouse Unigene: 453136 Mouse Unigene: 453137 Mouse Unigene: 42906 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.