RAS相關GTP結合蛋白A抗體

產品貨號：

BN40265R
中文名稱：

RAS相關GTP結合蛋白A抗體
英文名稱：

Rabbit anti-RRAGA + RRAGB Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40265R-100ul

100ul

￥2360.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
BN40265R-200ul

200ul

￥3490.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	RRAGA + RRAGB
中文名稱	RAS相關GTP結合蛋白A抗體
別名	FIP1; RAGA; FIP-1; RRAGB; Adenovirus E3 14.7 kDa-interacting protein 1; Rag A; RAg B; RagA; RAGB; Ras related GTP binding protein A; RRAGA_HUMAN; Ras-related GTP binding A； GTP-binding protein ragB; Rag B; RagB; Ras-related GTP-binding protein B; RRAGB; RRAGB_HUMAN..
研究領域	腫瘤細胞生物免疫學染色質和核信號信號轉導
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Dog, Pig, Horse, Sheep, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	37kDa
細胞定位	細胞核細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human RRAGA and RRAGB:231-313/313
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. Function: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Subunit: Binds GTP. Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein. Subcellular Location: Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. Tissue Specificity: Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. Similarity: Belongs to the GTR/RAG GTP-binding protein family. SWISS: Q7L523 Gene ID: 10670 Database links: Entrez Gene: 10670 Human Entrez Gene: 68441 Mouse Entrez Gene: 117044 Rat Omim: 612194 Human SwissProt: Q7L523 Human SwissProt: Q80X95 Mouse SwissProt: Q63486 Rat Unigene: 702275 Human Unigene: 31178 Mouse Unigene: 2816 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.