Rabbit anti-E2F3 Polyclonal antibody

產品貨號：

BN40667R
中文名稱：

Rabbit anti-E2F3 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40667R-100ul

100ul

￥2360.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,ICC,IF
BN40667R-200ul

200ul

￥3490.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,ICC,IF

產品描述

英文名稱	E2F3
中文名稱	轉錄因子E2F-3抗體
別名	DKFZp686C18211; E2F 3; E2F transcription factor 3; KIAA0075; MGC104598; Transcription factor E2F 3; E2F3_HUMAN; Transcription factor E2F3; E2F-3.
研究領域	免疫學染色質和核信號轉錄調節因子表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Dog, Horse, Rabbit, )
產品應用	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	49kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human E2F3:91-190/465
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq]. Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Subunit: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP. Subcellular Location: Nucleus. Similarity: Belongs to the E2F/DP family. SWISS: O00716 Gene ID: 1871 Database links: Entrez Gene: 1871 Human GenBank: AAH16847 Human Omim: 600427 Human SwissProt: O00716 Human Unigene: 269408 Human Unigene: 703174 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 轉錄調節因子（Transcriptin Regulators） E2F3轉錄因子具有調控細胞增殖、分化和凋亡相關基因轉錄的重要作用.