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    2. 最近搜索:細胞培養 微生物學 分子生物 生物化學
      首頁>>免疫學>>一抗>>c-fos抗體
      c-fos抗體
      • 產品貨號:
        BN41620R
      • 中文名稱:
        c-fos抗體
      • 英文名稱:
        Rabbit anti-c-fos Polyclonal antibody
      • 品牌:
        Biorigin
      • 貨號

        產品規格

        售價

        備注

      • BN41620R-50ul

        50ul

        ¥1486.00

        交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit) 推薦應用:IHC-P,IHC-F,ICC,IF,ELISA

      • BN41620R-100ul

        100ul

        ¥2360.00

        交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit) 推薦應用:IHC-P,IHC-F,ICC,IF,ELISA

      • BN41620R-200ul

        200ul

        ¥3490.00

        交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit) 推薦應用:IHC-P,IHC-F,ICC,IF,ELISA

      產品描述

      英文名稱c-fos
      中文名稱c-fos抗體
      別    名Cellular oncogene fos; FBJ murine osteosarcoma viral v fos oncogene homolog antibody FBJ Osteosarcoma Virus; FOS; FOS protein; G0 G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; v fos FBJ murine osteosarcoma viral oncogene homolog; AP-1; p55; FOS_HUMAN; Proto-oncogene c-Fos; G0/G1 switch regulatory protein 7.  



      研究領域腫瘤  細胞生物  免疫學  神經生物學  信號轉導  轉錄調節因子  腫瘤細胞生物標志物  
      抗體來源Rabbit
      克隆類型Polyclonal
      交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
      產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 (石蠟切片需做抗原修復)
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      分 子 量41kDa
      細胞定位細胞核 
      性    狀Liquid
      濃    度1mg/ml
      免 疫 原KLH conjugated synthetic peptide derived from human c-fos:145-260/380 
      亞    型IgG
      純化方法affinity purified by Protein A
      儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
      保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
      PubMedPubMed
      產品介紹The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008].

      Function:
      Nuclear phosphoprotein which forms a tight butnon-covalently linked complex with the JUN/AP-1 transcriptionfactor. In the heterodimer, FOS and JUN/AP-1 basic regions eachseems to interact with symmetrical DNA half sites. On TGF-betaactivation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at theAP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Hasa critical function in regulating the Has a critical function inregulating the development of cells destined to form and maintainthe skeleton. It is thought to have an important role in signaltransduction, cell proliferation and differentiation.

      Subunit:
      Heterodimer; with JUN (By similarity). Interacts withMAFB. Component of the SMAD3/SMAD4/JUN/FOS complexrequired for syngernistic TGF-beta-mediated transcription at theAP1 promoter site. Interacts with SMAD3; the interaction is weakeven on TGF-beta activation. Interacts with MAFB. Interacts withDSIPI; this interaction inhibits the binding of active AP1 to itstarget DNA.

      Subcellular Location:
      Nucleus.

      Post-translational modifications:
      Phosphorylated in the C-terminal upon stimulation by nervegrowth factor (NGF) and epidermal growth factor (EGF).Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on bothSer-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to proteinstabilization with phosphorylation on Ser-374 being the major sitefor protein stabilization on NGF stimulation. Phosphorylation onSer-362 and Ser-374 primes further phosphorylations on Thr-325 andThr-331 through promoting docking of MAPK to the DEF domain.Phosphorylation on Thr-232, induced by HA-RAS, activates thetranscriptional activity and antagonizes sumoylation.Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes toosteoblast transformation (By similarity). [PTM] Constitutively sumoylated by SUMO1, SUMO2 and SUMO3.Desumoylated by SENP2. Sumoylation requires heterodimerization withJUN and is enhanced by mitogen stimulation. Sumoylation inhibitsthe AP-1 transcriptional activity and is, itself, inhibited byRas-activated phosphorylation on Thr-232.

      Similarity:
      Belongs to the bZIP family. Fos subfamily.
      Contains 1 bZIP domain.

      SWISS:
      P01100

      Gene ID:
      2353

      Database links:

      Entrez Gene: 2353 Human

      Entrez Gene: 14281 Mouse

      Entrez Gene: 314322 Rat

      Omim: 164810 Human

      SwissProt: P01100 Human

      SwissProt: P01101 Mouse

      SwissProt: P12841 Rat

      Unigene: 246513 Mouse

      Unigene: 103750 Rat



      Important Note:
      This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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