D型-過氧化酶活化增生受體抗體

產品貨號：

BN41520R
中文名稱：

D型-過氧化酶活化增生受體抗體
英文名稱：

Rabbit anti-PPAR delta + beta Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41520R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41520R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41520R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱	PPAR delta + beta
中文名稱	D型-過氧化酶活化增生受體抗體
別名	PPAR delta+beta; FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN.
研究領域	心血管免疫學細胞膜受體
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, (predicted: Mouse, Rat, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	48kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from mouse PPAR-delta:2-100/440
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain. Function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous with maximal levels in placenta and skeletal muscle. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P35396 Gene ID: 5467 Database links: Entrez Gene: 5467 Human Entrez Gene: 19015 Mouse Entrez Gene: 25682 Rat Omim: 600409 Human SwissProt: Q03181 Human SwissProt: P35396 Mouse Unigene: 696032 Human Unigene: 328914 Mouse Unigene: 96181 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 類固醇受體（Steroid Receptors）研究人員指出該分子的功能，極可能就是阻斷心血管免疫發炎反應的訊號傳遞過程。PPAR－delta基因是控制肌肉發展的重要基因，在增加老鼠耐力的同時還能幫助它燃燒掉脂肪，研究人員發現，對于與新陳代謝有關的各項疾病，從心臟病到肥胖癥都有啟發性的意義，他可以阻止脂肪沉淀在動脈壁上，進而防止動脈硬化癥的發生,該蛋白參與脂肪代謝、肥胖、糖尿病、動脈硬化和癌癥的發病。在動脈硬化現象發生的早期，免疫細胞會促使血管慢性的發炎，因而造成血管不斷地吸收和輸送脂肪，進而導致脂肪的堆積與血管硬化，而PPAR-delta就像警衛分子一樣，時時降低發炎反應和抑制動脈硬化斑的形成，因此該分子應該是相關藥物研發，相當值得切入的目標。研究人員認為，這個發現將給藥廠研發治療心血管疾病的新藥提供新的線索。