半胱胺酸蛋白酶蛋白-6抗體

產品貨號：

BN41482R
中文名稱：

半胱胺酸蛋白酶蛋白-6抗體
英文名稱：

Rabbit anti-Caspase-6 subunit p18 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41482R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41482R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41482R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	Caspase-6 subunit p18
中文名稱	半胱胺酸蛋白酶蛋白-6抗體
別名	Caspase-6; Caspase-6 p18; cleaved Caspase-6 p18; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Human cysteine protease Mch2 isoform alpha; Mch 2; Mch2; CASP6_HUMAN; caspase-6 isoform alpha precursor.
研究領域	細胞生物神經生物學信號轉導細胞凋亡
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, (predicted: Rat, Dog, Rabbit, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	18/33kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Caspase-6 subunit p18:27-130/293
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Subcellular Location: Cytoplasm. Post-translational modifications: Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits. Similarity: Belongs to the peptidase C14A family. SWISS: P55212 Gene ID: 839 Database links: Entrez Gene: 839 Human Entrez Gene: 12368 Mouse Entrez Gene: 83584 Rat Omim: 601532 Human SwissProt: P55212 Human SwissProt: O08738 Mouse SwissProt: O35397 Rat Unigene: 654616 Human Unigene: 281379 Mouse Unigene: 88160 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Caspase-6 與Caspase-3有38%的同源性，屬胱氨酸-天冬氨酸蛋白酶家族。在凋亡執行階段起中心作用，可被Caspase-7、-8、-10剪切。它是唯一一個可以剪切核纖層蛋白的Caspase。