淋巴細胞性白血病相關序列1抗體

產品貨號：

BN41316R
中文名稱：

淋巴細胞性白血病相關序列1抗體
英文名稱：

Rabbit anti-LYL1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41316R-100ul

100ul

￥2360.00

交叉反應：Human(predicted:Mouse,Rat,Pig,Cow) 推薦應用：WB,Flow-Cyt,ELISA
BN41316R-200ul

200ul

￥3490.00

交叉反應：Human(predicted:Mouse,Rat,Pig,Cow) 推薦應用：WB,Flow-Cyt,ELISA

產品描述

英文名稱	LYL1
中文名稱	淋巴細胞性白血病相關序列1抗體
別名	Lyl1; Lymphoblastic leukemia derived sequence 1; Protein lyl 1.
研究領域	腫瘤細胞生物免疫學表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, (predicted: Mouse, Rat, Pig, Cow, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	31kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human LYL1:151-250/280
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The Lyl1 gene encodes a basic helix–loop–helix transcription factor involved in T-cell acute lymphoblastic leukemia. The expression of Lyl1 is at higher levels in the majority of cases of acute myeloblastic leukemia (AML) or myelodysplastic syndrome when compared to normal bone marrow. Lyl1 is highly expressed in most AML cell lines.Lyl-1, TAL1 and TAL2 are part of a family of basic helix-loop-helix (bHLH) proteins implicated in T cell acute leukemia. TAL1, also designated SCL, is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. TAL2 is a protein involved in T cell acute lymphoblastic leukemia through a chromosomal translocation involving TAL2 and T cell receptor ∫ chain genes. TAL2 includes a helix-loop-helix protein dimerization and DNA-binding domain that is homologous to TAL1 and Lyl-1 proto-oncogenes. Lyl-1 (lymphoblastic leukemia-derived sequence 1) is a nuclear protein. Endogenous Lyl-1 exists in complex with E2? proteins. Lyl-1 and E2? protein can form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Lyl-1 is involved in a chromosomal aberration which causes a form of T cell acute lymphoblastic leukemia (T-ALL). Function: Efficient DNA binding requires dimerization with another bHLH protein. Subcellular Location: Nucleus (Potential). DISEASE: Note=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: P12980 Gene ID: 4066 Database links: Entrez Gene: 4066 Human Entrez Gene: 17095 Mouse Entrez Gene: 304663 Rat Omim: 151440 Human SwissProt: P12980 Human SwissProt: P27792 Mouse SwissProt: Q66HH3 Rat Unigene: 46446 Human Unigene: 728534 Human Unigene: 4925 Mouse Unigene: 17352 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.