泛素結合酶E2變異體1抗體

產品貨號：

BN41282R
中文名稱：

泛素結合酶E2變異體1抗體
英文名稱：

Rabbit anti-UBE2V1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41282R-100ul

100ul

￥2360.00

交叉反應：Human,Rat(predicted:Mouse,Chicken,Pig,Horse,Sheep) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41282R-200ul

200ul

￥3490.00

交叉反應：Human,Rat(predicted:Mouse,Chicken,Pig,Horse,Sheep) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱	UBE2V1
中文名稱	泛素結合酶E2變異體1抗體
別名	CIR1; CROC-1; CROC1; CROC1A; TRAF6-regulated IKK activator 1 beta Uev1A; UB2V1_HUMAN; UBE2V 1; UBE2V; UBE2V1; Ubiquitin conjugating enzyme E2 variant 1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; UEV1.
研究領域	細胞生物染色質和核信號信號轉導細胞周期蛋白細胞分化表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Rat, (predicted: Mouse, Chicken, Pig, Horse, Sheep, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	16kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human UBE2V1:51-147/147
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Function: Has no ubiquitin ligase activity on its own. TheUBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonicalpoly-ubiquitin chains that are linked through Lys-63. This type ofpoly-ubiquitination activates IKK and does not seem to involveprotein degradation by the proteasome. Plays a role in theactivation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2.Mediates transcriptional activation of target genes. Plays a rolein the control of progress through the cell cycle anddifferentiation. Plays a role in the error-free DNA repair pathwayand contributes to the survival of cells after DNA damage. Subunit: Heterodimer with UBE2N. Interacts (UBE2V2-UBE2Nheterodimer) with the E3 ligase STUB1 (via the U-box domain); thecomplex has a specific 'Lys-63'-linked polyubiquitination activity.Interacts with TRAF6. Subcellular Location: Nucleus. Note=Excluded from the nucleolus. Tissue Specificity: Highly expressed in thyroid, pancreas, spinalcord, lymph node, trachea, adrenal gland, bone marrow and pancreas.Detected at low levels in heart, breast, placenta, brain, liver,kidney, stomach and lung. Similarity: Belongs to the ubiquitin-conjugating enzyme family. SWISS: Q13404 Gene ID: 387522 Database links: Entrez Gene: 387522 Human Entrez Gene: 7335 Human Entrez Gene: 66589 Mouse Entrez Gene: 296390 Rat Omim: 602995 Human SwissProt: Q13404 Human SwissProt: Q9CZY3 Mouse Unigene: 420529 Human Unigene: 727525 Human Unigene: 278783 Mouse Unigene: 360108 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.