細胞周期通道和神經細胞分化蛋白1抗體

產品貨號：

BN41279R
中文名稱：

細胞周期通道和神經細胞分化蛋白1抗體
英文名稱：

Rabbit anti-CEND1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41279R-100ul

100ul

￥2360.00

交叉反應：Mouse,Rat(predicted:Human,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41279R-200ul

200ul

￥3490.00

交叉反應：Mouse,Rat(predicted:Human,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	CEND1
中文名稱	細胞周期通道和神經細胞分化蛋白1抗體
別名	BM88; BM88 antigen; Cell cycle exit and neuronal differentiation 1; Cell cycle exit and neuronal differentiation protein 1; FLJ90066; MGC34326; CEND_HUMAN
研究領域	細胞生物神經生物學細胞周期蛋白細胞分化細胞類型標志物
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Horse, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	15kDa
細胞定位	細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human CEND1:4-100/149
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	BM88 is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A. Function: CEND1 is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. Subunit: Homodimer Subcellular Location: Membrane; Single-pass type IV membrane protein. Tissue Specificity: Neuron specific. Similarity: Belongs to the CEND1 family. SWISS: Q8N111 Gene ID: 51286 Database links: Entrez Gene: 51286 Human Entrez Gene: 57754 Mouse Entrez Gene: 361675 Rat Omim: 608213 Human SwissProt: Q8N111 Human SwissProt: Q9JKC6 Mouse SwissProt: Q5FVI4 Rat Unigene: 22140 Human Unigene: 87027 Mouse Unigene: 64460 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.