冷誘導RNA結合蛋白抗體

產品貨號：

BN41275R
中文名稱：

冷誘導RNA結合蛋白抗體
英文名稱：

Rabbit anti-CIRBP Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41275R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41275R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	CIRBP
中文名稱	冷誘導RNA結合蛋白抗體
別名	A18 hnRNP; A18HNRNP; cirbp; CIRBP_HUMAN; CIRP; Cold inducible RNA binding protein; Cold-inducible RNA-binding protein; Glycine rich RNA binding protein; Glycine-rich RNA-binding protein CIRP.
研究領域	細胞生物免疫學細胞周期蛋白表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	19kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human CIRBP:61-172/172
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. Subunit: Interacts with EIF4G1. Associates with ribosomes. Subcellular Location: Nucleus, nucleoplasm. Cytoplasm. Tissue Specificity: Ubiquitous. Post-translational modifications: Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity). Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation. Similarity: Contains 1 RRM (RNA recognition motif) domain. SWISS: Q14011 Gene ID: 1153 Database links: Entrez Gene: 1153 Human Omim: 602649 Human SwissProt: Q14011 Human Unigene: 618145 Human Unigene: 634522 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.