RAS相關蛋白癌基因Rab35抗體

產品貨號：

BN41272R
中文名稱：

RAS相關蛋白癌基因Rab35抗體
英文名稱：

Rabbit anti-RAB35 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41272R-100ul

100ul

￥2360.00

交叉反應：Human(predicted:Chicken,Dog,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41272R-200ul

200ul

￥3490.00

交叉反應：Human(predicted:Chicken,Dog,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱	RAB35
中文名稱	RAS相關蛋白癌基因Rab35抗體
別名	GTP binding protein RAY; GTP-binding protein RAY; H ray; RAB1C; Rab35; RAB35 member RAS oncogene family; RAB35, member RAS oncogene family; RAB35_HUMAN; Ras related protein rab 1c (GTP binding protein ray); Ras related protein Rab 1C; Ras related protein Rab35; Ras-related protein Rab-1C; Ras-related protein Rab-35; RAY.
研究領域	細胞生物細胞周期蛋白細胞分化 G蛋白信號
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, (predicted: Chicken, Dog, Cow, Horse, Rabbit, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	22kDa
細胞定位	細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human RAB35:131-201/201
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. Function: In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. Subunit: Interacts with DENND1A and DENND1B in a nucleotide-dependent manner. The low binding to DENND1C is nucleotide-independent. All 3 DENND1 act as GEFs for RAB35 and thus activate the protein. Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Melanosome. Post-translational modifications: AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB35 constitutively active. Phosphocholinated by L.pneumophila AnkX. Both GDP-bound and GTP-bound forms can be phosphocholinated. Phosphocholination inhibits the GEF activity of DENND1A. Similarity: Belongs to the small GTPase superfamily. Rab family. SWISS: Q15286 Gene ID: 11021 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.