MDM2樣P53蛋白結合抗體

產品貨號：

BN41260R
中文名稱：

MDM2樣P53蛋白結合抗體
英文名稱：

Rabbit anti-MDMX Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41260R-100ul

100ul

￥2360.00

交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41260R-200ul

200ul

￥3490.00

交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	MDMX
中文名稱	MDM2樣P53蛋白結合抗體
別名	Double minute 4; Double minute 4 human homolog of p53 binding protein; Double minute 4 protein; HDMX; MDM 4; Mdm2 like p53 binding protein; Mdm2-like p53-binding protein; MDM4; Mdm4 p53 binding protein homolog mouse; Mdm4 protein; MDM4 related protein 1; Mdm4 transformed 3T3 cell double minute 4; Mdm4 transformed 3T3 cell double minute 4 p53 binding protein; Mdm4 transformed 3T3 cell double minute 4 p53 binding protein mouse; MDM4_HUMAN; Mdmx protein; Mouse double minute 4 homolog; Mouse double minute 4 human homolog of; Mouse double minute 4 human homolog of p53 binding protein; MRP 1; MRP1; p53 binding protein; p53 BINDING PROTEIN MDM4; p53-BINDING PROTEIN MDM4; Protein Mdm4; Protein Mdmx.
研究領域	細胞生物信號轉導細胞凋亡表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	55kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human MDMX:301-400/490
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2. Function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. Subunit: Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with UPB2, MDM2 and MDM4. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53. Subcellular Location: Nucleus. Tissue Specificity: Expressed in all tissues tested with high levels in thymus. Post-translational modifications: Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent. Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein. Similarity: Belongs to the MDM2/MDM4 family. Contains 1 RanBP2-type zinc finger. Contains 1 RING-type zinc finger. Contains 1 SWIB domain. SWISS: O15151 Gene ID: 4194 Database links: Entrez Gene: 4194 Human Entrez Gene: 17248 Mouse Omim: 602704 Human SwissProt: O15151 Human SwissProt: O35618 Mouse Unigene: 497492 Human Unigene: 426531 Mouse Unigene: 476028 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.