G蛋白α亞單位蛋白Q抗體

產品貨號：

BN41193R
中文名稱：

G蛋白α亞單位蛋白Q抗體
英文名稱：

Rabbit anti-GNAQ Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41193R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,ELISA
BN41193R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,ELISA

產品描述

英文名稱	GNAQ
中文名稱	G蛋白α亞單位蛋白Q抗體
別名	G ALPHA q; G protein alpha Q; GAQ; Guanine nucleotide binding protein alpha q; Guanine nucleotide binding protein G q subunit alpha; GNAQ_HUMAN.
研究領域	腫瘤心血管細胞生物神經生物學信號轉導 G蛋白偶聯受體
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	42kDa
細胞定位	細胞核細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human GNAQ:51-150/359
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	GNAQ belong to the family of heterotrimeric Guanine nucleotide-binding proteins proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. GNAQ is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta. in recent studies over expression of GNAQ is associated with cardiomyocyte apoptosis. Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Binds SLC9A3R1. Forms a complex with PECAM1 and BDKRB2. Interacts with PECAM1. Subcellular Location: Nucleus (By similarity). Membrane (By similarity). Nucleus membrane (By similarity). Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). Tissue Specificity: Predominantly expressed in ovary, prostate, testis and colon. Similarity: Belongs to the G-alpha family. G(q) subfamily. SWISS: P50148 Gene ID: 2776 Database links: Entrez Gene: 2776 Human Entrez Gene: 14682 Mouse Entrez Gene: 654405 Pig Entrez Gene: 81666 Rat Omim: 600998 Human SwissProt: P50148 Human SwissProt: P21279 Mouse SwissProt: Q2PKF4 Pig SwissProt: P82471 Rat Unigene: 269782 Human Unigene: 439701 Mouse Unigene: 441601 Mouse Unigene: 22817 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Gαq是G蛋白家族成員之一,是Gq蛋白的功能單位。其功能為傳導來自GPCR的信號到細胞內。研究證明,Gαq與免疫細胞活化、增殖、死亡、分化、遷移,細胞因子分泌以及自身免疫等均有非常密切的關系。