kelch樣蛋白7抗體

產品貨號：

BN41180R
中文名稱：

kelch樣蛋白7抗體
英文名稱：

Rabbit anti-KLHL7 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41180R-100ul

100ul

￥2360.00

交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應用：IHC-P,IHC-F,IF,ELISA
BN41180R-200ul

200ul

￥3490.00

交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應用：IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	KLHL7
中文名稱	kelch樣蛋白7抗體
別名	Kelch like protein 7; kelch-like 6; kelch-like 7; kelch/BTB.KLHL7_HUMAN
研究領域	腫瘤免疫學染色質和核信號
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Chicken, Dog, Pig, Cow, Horse, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	64kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human KLHL7:51-150/856
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010]. Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. Subunit: Homodimer. Component of the BCR(KLHL7) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL7 and RBX1. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed, with highest levels in adult and fetal heart, CNS and adult testis. DISEASE: Defects in KLHL7 are the cause of retinitis pigmentosa type 42 (RP42) [MIM:612943]. A retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Similarity: Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. SWISS: Q8IXQ5 Gene ID: 55975 Database links: Entrez Gene: 55975 Human Entrez Gene: 52323 Mouse Entrez Gene: 362303 Rat Omim: 611119 Human SwissProt: Q8IXQ5 Human SwissProt: Q8BUL5 Mouse SwissProt: Q5XHZ6 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.